Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications
نویسندگان
چکیده
منابع مشابه
Conotoxins: Therapeutic Potential and Application
The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides. Most conotoxins characterized to date target receptors and ion channels of excitable tissues, such as ligandgated nicotinic acetylcholine, N-methyl-D-aspart...
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The neurotoxins isolated from cone shell venoms are a diverse group of small, disulfiderich peptides. Most of the active peptides isolated to date have been shown to specifically target various components of neural transmission, and have generally demonstrated high specificities for ion channel and receptor types and subtypes. The specificity of conotoxins is one of the attributes that make the...
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Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and diseased states, as well as being a collecti...
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ژورنال
عنوان ژورنال: Current Pharmaceutical Design
سال: 2016
ISSN: 1381-6128
DOI: 10.2174/1381612822666151124234715